Intravenous aminophylline and cerebral blood flow in preterm infants.
作者信息
McDonnell M, Ives N K, Hope P L
机构信息
Department of Paediatrics, John Radcliffe Hospital, Oxford.
出版信息
Arch Dis Child. 1992 Apr;67(4 Spec No):416-8. doi: 10.1136/adc.67.4_spec_no.416.
Abstract
The effect of aminophylline on cerebral blood flow (CBF) was studied in 10 preterm infants who were receiving 6.2 mg/kg intravenously over 20 minutes followed by a maintenance infusion. CBF was measured intermittently using near infrared spectroscopy. Heart rate, blood pressure, oxygen saturation, and transcutaneously measured carbon dioxide tension (TcPCO2) were recorded continuously. Aminophylline administration was associated with a fall in CBF from a median of 15.9 ml/100 g/min to 11.2 ml/100 g/min. Median fall in CBF was 4.1 ml/100 g/min (95% confidence interval 1.7 to 6.5). Heart rate rose and TcPCO2 fell in all infants, median fall being 0.66 kPa. The reduction in CBF was greater than would be expected on the basis of the modest fall in TcPCO2.
摘要
相似文献
1
Intravenous aminophylline and cerebral blood flow in preterm infants.
Arch Dis Child. 1992 Apr;67(4 Spec No):416-8. doi: 10.1136/adc.67.4_spec_no.416.
2
Effect of aminophylline on cerebral haemodynamics and oxidative metabolism in premature infants.
Eur J Pediatr. 1994 Feb;153(2):123-8. doi: 10.1007/BF01959223.
3
Aminophylline therapy and cerebral blood flow velocity in preterm infants.
J Paediatr Child Health. 1994 Apr;30(2):123-5. doi: 10.1111/j.1440-1754.1994.tb00594.x.
4
Aminophylline reduces cerebral blood flow in stable, preterm infants without affecting the visual evoked potential.
Eur J Pediatr. 1991 Mar;150(5):366-9. doi: 10.1007/BF01955942.
5
Brain hemodynamic changes in preterm infants after maintenance dose caffeine and aminophylline treatment.
Biol Neonate. 2000 Jul;78(1):27-32. doi: 10.1159/000014243.
6
Aminophylline and Doppler time-averaged mean velocity in the middle cerebral artery in preterm neonates.
J Paediatr Child Health. 1995 Oct;31(5):461-4. doi: 10.1111/j.1440-1754.1995.tb00858.x.
7
Acute effects of acetazolamide on cerebral blood flow velocity and pCO2 in the newborn infant.
Acta Paediatr Scand. 1991 Jan;80(1):22-7. doi: 10.1111/j.1651-2227.1991.tb11724.x.
8
Effect of caffeine on cerebral blood flow velocity in preterm infants.
Biol Neonate. 1989;56(4):198-203. doi: 10.1159/000243123.
9
Haemodynamic responses and population pharmacokinetics of midazolam following administration to ventilated, preterm neonates.
J Paediatr Child Health. 1997 Aug;33(4):335-8. doi: 10.1111/j.1440-1754.1997.tb01611.x.
10
Cerebral blood flow velocity assessed by Doppler technique after intravenous application of diazepam in very low birth weight infants.
Dev Pharmacol Ther. 1989;14(2):102-7.
引用本文的文献
1
Precision caffeine therapy for apnea of prematurity and circadian rhythms: New possibilities open up.
Front Pharmacol. 2022 Dec 1;13:1053210. doi: 10.3389/fphar.2022.1053210. eCollection 2022.
2
Effects of a divided high loading dose of caffeine on circulatory variables in preterm infants.
Arch Dis Child Fetal Neonatal Ed. 2006 Jan;91(1):F61-4. doi: 10.1136/adc.2005.073866.
3
Treatment of apnea of prematurity.
Paediatr Drugs. 2003;5(3):195-210. doi: 10.2165/00128072-200305030-00006.
4
Effect of aminophylline on cerebral haemodynamics and oxidative metabolism in premature infants.
Eur J Pediatr. 1994 Feb;153(2):123-8. doi: 10.1007/BF01959223.
5
Near infrared spectroscopy.
Eur J Pediatr. 1995;154(8 Suppl 3):S19-21. doi: 10.1007/BF02155107.
本文引用的文献
1
The effects of intravenously administered aminophylline on cerebral circulation and metabolism in man.
J Clin Invest. 1950 Jan;29(1):28-30. doi: 10.1172/JCI102230.
2
Aminophylline reduces cerebral blood flow velocity in low-birth-weight infants.
Am J Dis Child. 1984 May;138(5):489-91. doi: 10.1001/archpedi.1984.02140430065017.
3
Cardiac output changes secondary to theophylline therapy in preterm infants.
J Pediatr. 1986 Nov;109(5):874-6. doi: 10.1016/s0022-3476(86)80717-x.
4
Cotside measurement of cerebral blood flow in ill newborn infants by near infrared spectroscopy.
Lancet. 1988 Oct 1;2(8614):770-1. doi: 10.1016/s0140-6736(88)92418-x.
5
Quantification of cerebral oxygenation and haemodynamics in sick newborn infants by near infrared spectrophotometry.
Lancet. 1986 Nov 8;2(8515):1063-6. doi: 10.1016/s0140-6736(86)90467-8.
6
Regional cerebral blood flow velocity after aminophylline therapy in premature newborn infants.
J Pediatr. 1989 May;114(5):870-3. doi: 10.1016/s0022-3476(89)80155-6.
7
Effect of caffeine on cerebral blood flow velocity in preterm infants.
Biol Neonate. 1989;56(4):198-203. doi: 10.1159/000243123.
8
Cerebral blood flow reactivity in spontaneously breathing, preterm infants shortly after birth.
Acta Paediatr Scand. 1990 Apr;79(4):391-6. doi: 10.1111/j.1651-2227.1990.tb11482.x.
9
Aminophylline reduces cerebral blood flow in stable, preterm infants without affecting the visual evoked potential.
Eur J Pediatr. 1991 Mar;150(5):366-9. doi: 10.1007/BF01955942.
10
Effects of indomethacin on cerebral haemodynamics in very preterm infants.
Lancet. 1990 Jun 23;335(8704):1491-5. doi: 10.1016/0140-6736(90)93030-s.
Zotero 插件