Rosenkrantz T S, Oh W
Am J Dis Child. 1984 May;138(5):489-91. doi: 10.1001/archpedi.1984.02140430065017.
Cerebral blood flow decreases substantially in the adult after a single bolus injection of aminophylline. To determine if the cerebral circulation of the low-birth-weight infant behaves in a similar manner, we measured cerebral blood flow velocity (CBFV) in the anterior cerebral arteries of nine infants treated with an intravenous bolus dose of 5 mg/kg of body weight of aminophylline. A reduction in CBFV of 21% and 17% was observed at 60 and 120 minutes following the aminophylline administration. There was a concurrent substantial reduction in PCO2 from 45 +/- 7 to 39 +/- 7 mm Hg before and 120 minutes after the aminophylline administration, respectively. The reduction in CBFV may be the result of a reduction in PCO2 resulting from aminophylline treatment.
在成人大剂量单次注射氨茶碱后，脑血流量会大幅下降。为了确定低体重儿的脑循环是否有类似表现，我们测量了9名接受静脉注射5毫克/千克体重氨茶碱的婴儿大脑前动脉的脑血流速度（CBFV）。在注射氨茶碱后的60分钟和120分钟，观察到CBFV分别降低了21%和17%。同时，氨茶碱注射前和注射后120分钟，PCO2从45±7毫米汞柱大幅降至39±7毫米汞柱。CBFV的降低可能是氨茶碱治疗导致PCO2降低的结果。
