系统性红斑狼疮患者患癌风险增加。
Increased risk of cancer in patients with systemic lupus erythematosus.
作者信息
Pettersson T, Pukkala E, Teppo L, Friman C
机构信息
Fourth Department of Medicine, Helsinki University Central Hospital, Finland.
出版信息
Ann Rheum Dis. 1992 Apr;51(4):437-9. doi: 10.1136/ard.51.4.437.
Abstract
To evaluate the risk of cancer in patients with systemic lupus erythematosus (SLE) a series of 205 consecutive patients (182 women and 23 men) were followed up for cancer through the files of the Finnish Cancer Registry. The follow up consisted of a total of 2340 person years. Fifteen cancers were diagnosed against 5.7 expected (relative risk (RR) 2.6, 95% confidence interval (CI) 1.5 to 4.4). Among the women there were four non-Hodgkin's lymphomas against 0.09 expected (RR 44, CI 11.9 to 111) and two soft tissue sarcomas against 0.04 expected (RR 49, CI 6.0 to 177). When evaluated by a case control study previous treatment with cytostatic drugs showed no influence on the occurrence of cancer in this series of patients with SLE.
摘要
为评估系统性红斑狼疮（SLE）患者的癌症风险，通过芬兰癌症登记处的档案对连续的205例患者（182名女性和23名男性）进行了癌症随访。随访总计2340人年。共诊断出15例癌症，而预期为5.7例（相对风险（RR）2.6，95%置信区间（CI）1.5至4.4）。在女性患者中，有4例非霍奇金淋巴瘤，预期为0.09例（RR 44，CI 11.9至111），2例软组织肉瘤，预期为0.04例（RR 49，CI 6.0至177）。通过病例对照研究评估时，在这组SLE患者中，先前使用细胞毒性药物治疗对癌症的发生没有影响。
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