用于通过基质辅助激光解吸电离飞行时间质谱法改进磷脂分析的离子液体基质。
Ionic-liquid matrices for improved analysis of phospholipids by MALDI-TOF mass spectrometry.
作者信息
Li Ying L, Gross Michael L, Hsu Fong-Fu
机构信息
Department of Chemistry, Washington University, St. Louis, Missouri 63130, USA.
出版信息
J Am Soc Mass Spectrom. 2005 May;16(5):679-82. doi: 10.1016/j.jasms.2005.01.017.
The use of ionic liquid matrices (ILMs) for phospholipids (PLs) affords higher signal intensity, smaller spot size, improved spot homogeneity, better signal reproducibility, and comparable or better detection limits compared to that of the crystalline matrix 2,5-dihydroxybenzoic acid (2,5-DHB). The ionization products are comparable to those with 2,5-DHB although the use of ILMs gives a stronger tendency to produce alkali-metal-ion adducts and a lower extent of prompt fragmentation.
与结晶基质2,5-二羟基苯甲酸（2,5-DHB）相比，使用离子液体基质（ILM）分析磷脂（PL）可提供更高的信号强度、更小的斑点尺寸、更好的斑点均匀性、更好的信号重现性以及相当或更低的检测限。尽管使用ILM会产生更强的生成碱金属离子加合物的倾向和更低程度的快速碎片化，但电离产物与使用2,5-DHB时相当。
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