芳基砜类：一类新型的γ-分泌酶抑制剂。
Aryl sulfones: a new class of gamma-secretase inhibitors.
作者信息
Teall Martin, Oakley Paul, Harrison Timothy, Shaw Duncan, Kay Euan, Elliott Jason, Gerhard Ute, Castro José L, Shearman Mark, Ball Richard G, Tsou Nancy N
机构信息
Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK.
出版信息
Bioorg Med Chem Lett. 2005 May 16;15(10):2685-8. doi: 10.1016/j.bmcl.2004.12.017.
PMID:15863342
Abstract
The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described.
摘要
本文描述了一系列新型的4-芳基、4-苯基磺酰基环己烷酮衍生的γ-分泌酶抑制剂的开发，用于潜在治疗阿尔茨海默病。
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