Jelley Richard A, Elliott Jason, Gibson Karl R, Harrison Timothy, Beher Dirk, Clarke Earl E, Lewis Huw D, Shearman Mark, Wrigley Jonathan D J
Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK.
Bioorg Med Chem Lett. 2006 Jul 15;16(14):3839-42. doi: 10.1016/j.bmcl.2006.04.019. Epub 2006 May 6.
Previously, chemistry effort on the gem-cyclohexane series of gamma-secretase inhibitors has focused on the 4-position of the cyclohexane ring. Recently chemistry has been directed towards the 3-position and substitution here has also provided compounds with high gamma-secretase activity.
此前，针对γ-分泌酶抑制剂的宝石型环己烷系列的化学研究工作主要集中在环己烷环的4位。最近，化学研究方向转向了3位，在此处进行取代也得到了具有高γ-分泌酶活性的化合物。
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