I型和II型酒精中毒男性的酒精和乙醛脱氢酶多态性
Alcohol and aldehyde dehydrogenase polymorphisms in men with type I and Type II alcoholism.
作者信息
Chai Young-Gyu, Oh Dong-Yul, Chung Eun Kee, Kim Gil Sook, Kim Leen, Lee Yu-Sang, Choi Ihn-Geun
机构信息
Department of Biochemistry and Molecular Biology, Hanyang University College of Sciences, Ansan, Korea.
出版信息
Am J Psychiatry. 2005 May;162(5):1003-5. doi: 10.1176/appi.ajp.162.5.1003.
OBJECTIVE
The authors examined the genetic polymorphisms of alcohol dehydrogenase 2 and 3 (ADH2 and ADH3) and aldehyde dehydrogenase (ALDH2) in patients diagnosed as having Cloninger's type I or type II alcoholism.
METHOD
Seventy-two alcoholic men and 38 nonalcoholic, healthy men were tested for the distribution of genotypes and alleles of ADH2, ADH3, and ALDH2. Forty-eight of the alcoholic men had type I alcoholism, and 24 had type II alcoholism.
RESULTS
The frequencies of ADH21 and ADH32 alleles were significantly higher in men with type II alcoholism than in men with type I alcoholism and healthy men. The frequency of the ALDH2*1 allele was significantly higher in men with alcohol dependence than in healthy men.
CONCLUSIONS
The genetic characteristics of alcohol dehydrogenases in men with type I alcoholism were similar to those of healthy men, and the genetic characteristics of aldehyde dehydrogenase in men with type I alcoholism were similar to those of men with type II alcoholism. These findings suggest that the genetic characteristics of alcohol metabolism in type I alcoholism fall between nonalcoholism and type II alcoholism.
目的
作者检测了被诊断为克隆宁格I型或II型酒精中毒患者的乙醇脱氢酶2和3（ADH2和ADH3）以及乙醛脱氢酶（ALDH2）的基因多态性。
方法
对72名男性酗酒者和38名非酗酒健康男性进行ADH2、ADH3和ALDH2基因型及等位基因分布检测。其中48名男性酗酒者为I型酒精中毒，24名男性酗酒者为II型酒精中毒。
结果
II型酒精中毒男性中ADH21和ADH32等位基因频率显著高于I型酒精中毒男性和健康男性。酒精依赖男性中ALDH2*1等位基因频率显著高于健康男性。
结论
I型酒精中毒男性乙醇脱氢酶的遗传特征与健康男性相似，I型酒精中毒男性乙醛脱氢酶的遗传特征与II型酒精中毒男性相似。这些发现表明，I型酒精中毒的酒精代谢遗传特征介于非酒精中毒和II型酒精中毒之间。
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