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胎儿先天性肥胖型星形细胞瘤。

Congenital gemistocytic astrocytoma in a fetus.

作者信息

Nozaki Michimasa, Ohnishi Akiko, Fujimaki Takamitsu, Nagashima Kazuo, Cho Kazutoshi, Sawamura Yutaka

机构信息

Department of Neurosurgery, Kin-ikyo Chuo Hospital, Sapporo, Japan.

出版信息

Childs Nerv Syst. 2006 Feb;22(2):168-71. doi: 10.1007/s00381-004-1109-x. Epub 2005 Apr 30.

Abstract

INTRODUCTION

Congenital brain tumors, especially tumors diagnosed before birth, are very rare. This report presents a case of a congenital gemistocytic astrocytoma diagnosed by antenatal intrauterine ultrasound.

CASE REPORT

An intrauterine MRI revealed hydrocephalus and a mass lesion including massive hemorrhage in the right occipital lobe of a fetus. The patient was delivered by cesarean section and a total excision of the hemorrhagic tumor was carried out on the third day of his life. The histological study revealed gemistocytic astrocytoma (WHO grade II). Neither adjuvant chemotherapy nor radiation was given after the first surgery. Ten months after his birth, a recurrent tumor was depicted on follow-up MRI. The second total excision of the recurrent tumor and chemotherapy using cisplatin and vincristine were performed.

OUTCOME

The patient is free of disease at the age of 2 years and 6 months.

摘要

引言

先天性脑肿瘤,尤其是在出生前被诊断出的肿瘤,非常罕见。本报告介绍了一例通过产前宫内超声诊断出的先天性肥胖型星形细胞瘤病例。

病例报告

宫内磁共振成像显示一名胎儿存在脑积水以及一个包括右枕叶大量出血的肿块病变。该患者通过剖宫产分娩,并在其出生第三天对出血性肿瘤进行了全切。组织学研究显示为肥胖型星形细胞瘤(世界卫生组织二级)。首次手术后未进行辅助化疗或放疗。出生十个月后,随访磁共振成像显示肿瘤复发。对复发性肿瘤进行了第二次全切,并使用顺铂和长春新碱进行化疗。

结果

该患者在2岁6个月时无疾病迹象。

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