Al-Omar Mohamed A, Youssef Khairia M, El-Sherbeny Magda A, Awadalla Sit Albanat A, El-Subbagh Hussein I
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Arch Pharm (Weinheim). 2005 Apr;338(4):175-80. doi: 10.1002/ardp.200400953.
A new series of pyrano[3,2-c]pyridines, pyrazolo[4,3-c]pyridines, and pyrido[4,3-d]pyrimidines were synthesized and screened for their in vitro antioxidant activity. Compounds 13, 14, 15, 23, 29, 30, and 31 exhibited the most active oxygen free-radical scavenger activity with percentage inhibitions of 99.4, 99.6, 99.8, 97.3, 99.0, 99.3, and 99.5%; respectively, which is comparable to the curcumin potency. Most of the tested compounds proved to be safe towards peripheral multinuclear neutrophils (PMNs). The detailed synthesis and antioxidant activity data are reported.
合成了一系列新的吡喃并[3,2 - c]吡啶、吡唑并[4,3 - c]吡啶和吡啶并[4,3 - d]嘧啶，并对其体外抗氧化活性进行了筛选。化合物13、14、15、23、29、30和31表现出最强的活性氧自由基清除活性，抑制率分别为99.4%、99.6%、99.8%、97.3%、99.0%、99.3%和99.5%；与姜黄素的效力相当。大多数测试化合物对周围多核中性粒细胞（PMN）证明是安全的。报告了详细的合成和抗氧化活性数据。
