Fukunaga Masaharu
Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan.
APMIS. 2005 Apr;113(4):296-300. doi: 10.1111/j.1600-0463.2005.apm_09.x.
A case of osteogenic melanoma arising in the sole of the foot of a 75-year-old male is described. The patient had a history of cutaneous malignant melanoma of the left sole from 15 years previously with local recurrence 5 years previously. A second recurrence presented as an unencapsulated, poorly circumscribed mass measuring 7.5x6x3 cm, located in the dermis, subcutis and muscle, and composed of a lobular growth of malignant osteocartilaginous elements with foci of epithelioid cells. The tumor was strongly positive for HMB45 and S-100 protein. No conventional melanoma was found in the skin. The patient had no evidence of recurrence or metastasis 10 months after surgery. Pathologists and clinicians should be aware of the existence of osteogenic melanoma and should differentiate it from mimics.
本文描述了一例发生于一名75岁男性足底的成骨性黑色素瘤病例。该患者15年前有左足底皮肤恶性黑色素瘤病史，5年前局部复发。第二次复发表现为一个无包膜、边界不清的肿块，大小为7.5×6×3cm，位于真皮、皮下组织和肌肉内，由恶性骨软骨成分的小叶状生长构成，伴有上皮样细胞灶。肿瘤HMB45和S-100蛋白呈强阳性。皮肤中未发现传统型黑色素瘤。术后10个月，患者无复发或转移迹象。病理学家和临床医生应认识到成骨性黑色素瘤的存在，并应将其与相似病变相鉴别。
