Erdoğan Gülgün, Ozel Esin, Peştereli Hadice Elif, Salar Zeki, Tirak Bilal, Karaveli Seyda
Department of Pathology, Akdeniz University School of Medicine, Antalya, Turkey.
APMIS. 2005 Apr;113(4):301-3. doi: 10.1111/j.1600-0463.2005.apm_10.x.
A 76-year-old woman presented with a large calcifying mass behind the bladder. The tumor contained solid areas of a yellowish white color. Microscopic examination revealed highly cellular solid areas with many typical ependymal perivascular pseudorosettes. The cells contained uniform round-to-oval nuclei, some of which had irregular contours, clumped chromatin and occasional prominent nucleoli. There was widespread geographic necrosis and there were 5 atypical mitotic figures per 10 high power fields. Glial fibrillary acidic protein (GFAP) immunopositivity was observed in the cytoplasm of the tumor cells. Based on the histopathologic and immunohistochemical features, the tumor was diagnosed as an anaplastic ependymoma. This is to the best of our knowledge only the second case of anaplastic ependymoma in the medical literature.
