RNA沉默与基因组调控。

RNA silencing and genome regulation.

作者信息

Almeida Ricardo, Allshire Robin C

机构信息

Wellcome Trust Centre for Cell Biology, 6.34 Swann Building, King's Buildings, University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK.

出版信息

Trends Cell Biol. 2005 May;15(5):251-8. doi: 10.1016/j.tcb.2005.03.006.

DOI:10.1016/j.tcb.2005.03.006

PMID:15866029

Abstract

Closely related RNA silencing phenomena such as posttranscriptional and transcriptional gene silencing (PTGS and TGS), quelling and RNA interference (RNAi) represent different forms of a conserved ancestral process. The biological relevance of these RNA-directed mechanisms of silencing in gene regulation, genome defence and chromosomal structure is rapidly being unravelled. Here, we review the recent developments in the field of RNA silencing in relation to other epigenetic phenomena and discuss the significance of this process and its targets in the regulation of modern eukaryotic genomes.

摘要

紧密相关的RNA沉默现象，如转录后基因沉默和转录基因沉默（PTGS和TGS）、基因压制和RNA干扰（RNAi），代表了一个保守的祖先过程的不同形式。这些由RNA介导的沉默机制在基因调控、基因组防御和染色体结构中的生物学相关性正迅速被揭示。在这里，我们回顾了RNA沉默领域与其他表观遗传现象相关的最新进展，并讨论了这一过程及其靶点在现代真核生物基因组调控中的意义。