Ohara Koichi, Tanabu Shigeru, Yoshida Kimiko, Sato Yumi, Shibuya Haruo
Clinical Research Institute, National Minami Hanamaki Hospital, Hanamaki, Japan.
Prog Neuropsychopharmacol Biol Psychiatry. 2005 May;29(4):617-20. doi: 10.1016/j.pnpbp.2005.01.005.
Although the precise etiology of schizophrenia remains unknown, the development of schizophrenia has been associated with a history of obstetric complication (OC). Furthermore, some studies show structural and functional brain abnormalities in the unaffected siblings of schizophrenics. In this study the perinatal histories of 18 unaffected siblings of schizophrenics and 15 unrelated healthy controls, as detailed in their mothers' Maternal and Child Health Handbook records, were retrospectively analyzed. Records were scored for obstetric complication by the method developed by [Parnas, J., Schulsinger, F., Teasdale, T.W., Shulsinger, H., Feldman, P.M., Mednick, S.A., 1982. Perinatal complications and clinical outcome within the schizophrenia spectrum. Br. J. Psychiatry 140, 416-420]. The authors found the sibling group had greater pregnancy and birth complication (PBC) frequency, severity and total scores than the control population.
尽管精神分裂症的确切病因尚不清楚，但精神分裂症的发病与产科并发症（OC）病史有关。此外，一些研究表明，精神分裂症患者未患病的兄弟姐妹存在大脑结构和功能异常。在本研究中，回顾性分析了18名精神分裂症患者未患病的兄弟姐妹和15名无血缘关系的健康对照者的围产期病史，这些病史详细记录在他们母亲的《母婴健康手册》中。按照[帕尔纳斯，J.，舒尔辛格，F.，蒂斯代尔，T.W.，舒尔辛格，H.，费尔德曼，P.M.，梅德尼克，S.A.，1982年。精神分裂症谱系内的围产期并发症与临床结局。《英国精神病学杂志》140，416 - 420]所开发的方法对产科并发症记录进行评分。作者发现，兄弟姐妹组的妊娠和分娩并发症（PBC）频率、严重程度及总分均高于对照组人群。
