容量性钙内流：感知钙库
Capacitative calcium entry: sensing the calcium stores.
作者信息
Putney James W
机构信息
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
出版信息
J Cell Biol. 2005 May 9;169(3):381-2. doi: 10.1083/jcb.200503161. Epub 2005 May 2.
A long-standing mystery in the cell biology of calcium channel regulation is the nature of the signal linking intracellular calcium stores to plasma membrane capacitative calcium entry channels. An RNAi-based screen of selected Drosophila genes has revealed that a calcium-binding protein, stromal interaction molecule (STIM), plays an essential role in the activation of these channels and may be the long sought sensor of calcium store content.
钙通道调节的细胞生物学中一个长期存在的谜团是，将细胞内钙库与质膜容量性钙内流通道相联系的信号的本质。一项基于RNA干扰的对选定果蝇基因的筛选表明，一种钙结合蛋白——基质相互作用分子（STIM），在这些通道的激活中起关键作用，并且可能就是长期以来寻找的钙库含量传感器。
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