Thoenes G H, Pielsticker K, Schubert G
Lab Invest. 1979 Oct;41(4):321-33.
Kidney transplantation between major histocompatibility system-identical rat strains LEW.1N (donor) and BN (recipient) is regularly followed by serious immune complex (membranous) glomerulonephritis. The disease localizes in the transplant only and spares the recipient's own contralateral kidney. The recipients develop both circulating immune complexes, as well as circulating antibodies against an allogeneic, tubular epithelial antigen of the donor. Antibodies eluted from the diseased kidneys display the same specificity. The transplant disease, therefore, is not autoimmune glomerulonephritis but an alloimmune, organ-specific illness unrelated to the usual histocompatibility system.
在主要组织相容性系统相同的大鼠品系LEW.1N（供体）和BN（受体）之间进行肾脏移植后，通常会出现严重的免疫复合物（膜性）肾小球肾炎。该疾病仅局限于移植肾，而受体自身的对侧肾脏不受影响。受体既产生循环免疫复合物，也产生针对供体同种异体肾小管上皮抗原的循环抗体。从患病肾脏洗脱的抗体显示出相同的特异性。因此，移植肾疾病不是自身免疫性肾小球肾炎，而是一种与通常的组织相容性系统无关的同种异体免疫、器官特异性疾病。
