Hakoda Masayuki, Masunari Naomi, Yamada Michiko, Fujiwara Saeko, Suzuki Gen, Kodama Kazunori, Kasagi Fumiyoshi
Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan.
J Rheumatol. 2005 May;32(5):906-12.
To elucidate the association of serum uric acid concentration with cardiovascular mortality risk.
Serum uric acid level measured from 1966 through 1970 in 10,615 Japanese individuals from a cohort of atomic bomb survivors was analyzed for association with subsequent cardiovascular and all-cause mortality until 1999 using the Cox proportional hazard model.
During an average followup of 24.9 years, 5225 deaths occurred, of which 1984 were ascribed to cardiovascular disease. In men, after adjustment for age, elevated serum uric acid level was associated with both cardiovascular and all-cause mortality. After additional adjustment for potential cardiovascular disease risk factors including body mass index, smoking status, alcohol consumption, systolic blood pressure, cholesterol level, and histories of hypertension, diabetes and cardiovascular disease, elevated serum uric acid level in men was associated with all-cause mortality but not with cardiovascular mortality. In women, even after these adjustments, elevated serum uric acid level was significantly associated with cardiovascular and all-cause mortality.
Increased serum uric acid level is a significant and independent risk factor for cardiovascular mortality in women and for all-cause mortality in both men and women.
阐明血清尿酸浓度与心血管疾病死亡风险之间的关联。
对1966年至1970年间从原子弹幸存者队列中选取的10615名日本人的血清尿酸水平进行测量，并使用Cox比例风险模型分析其与截至1999年的后续心血管疾病和全因死亡率之间的关联。
在平均24.9年的随访期间，共发生5225例死亡，其中1984例归因于心血管疾病。在男性中，调整年龄后，血清尿酸水平升高与心血管疾病死亡率和全因死亡率均相关。在进一步调整包括体重指数、吸烟状况、饮酒量、收缩压、胆固醇水平以及高血压、糖尿病和心血管疾病病史等潜在心血管疾病风险因素后，男性血清尿酸水平升高与全因死亡率相关，但与心血管疾病死亡率无关。在女性中，即使经过这些调整，血清尿酸水平升高仍与心血管疾病死亡率和全因死亡率显著相关。
血清尿酸水平升高是女性心血管疾病死亡率以及男性和女性全因死亡率的重要独立危险因素。
