Bird B R, Myers D, Ryan S M, Wyse G, O'Sullivan S T, Breathnach O S
Department of Medical Oncology, Cork University Hospital, Wilton, Cork.
Ir J Med Sci. 2005 Jan-Mar;174(1):58-60. doi: 10.1007/BF03168521.
Merkel cell cancer (MCC) is an uncommon neuroendocrine skin cancer occurring predominantly in elderly Caucasians. It tends to metastasize to regional lymph nodes and viscera and is sensitive to chemotherapy but recurs rapidly.
To report one such case, its response to chemotherapy and briefly review the literature.
A 73-year-old male with a fungating primary lesion on his left knee and ulcerated inguinal lymph nodes was diagnosed with MCC and treated with chemotherapy. The two largest case series and reviews of case reports were summarised.
His ulcer healed after two cycles of carboplatin and etoposide with improvement in quality of life. Overall response rates of nearly 60% to chemotherapy are reported but median survival is only nine months with metastatic disease.
Chemotherapy should be considered for fit elderly patients with MCC who have recurrent or advanced disease.
默克尔细胞癌（MCC）是一种罕见的神经内分泌皮肤癌，主要发生于老年白种人。它易于转移至区域淋巴结和内脏，对化疗敏感但复发迅速。
报告这样一例病例、其对化疗的反应并简要回顾文献。
一名73岁男性，左膝有溃疡性原发损害且腹股沟淋巴结溃疡，被诊断为MCC并接受化疗。总结了两个最大的病例系列及病例报告综述。
经两个周期的卡铂和依托泊苷治疗后，他的溃疡愈合，生活质量得到改善。据报道，化疗的总体缓解率近60%，但转移性疾病的中位生存期仅为9个月。
对于患有复发性或晚期疾病的适合的老年MCC患者，应考虑化疗。
