Raebel M A, Browne B A
Scott and White, Temple, Texas.
Clin Podiatr Med Surg. 1992 Apr;9(2):409-23.
Clindamycin continues to be an important agent for the management of infections due to gram-positive cocci and anaerobes. Such pathogens are frequently important in skin, soft tissue, and deep infections of the foot. Erythromycin has an impressive safety record and has retained its activity against many organisms, including several that play a role in infections of the foot. Clindamycin and erythromycin are frequently used as alternatives to the penicillins and cephalosporins. Newer macrolides, in comparison to erythromycin, have similar antimicrobial spectra of activity, improved pharmacokinetic parameters, and better tissue penetration. As new microorganisms emerge as clinical problems, newer macrolides may play a therapeutic role.
克林霉素仍然是治疗革兰氏阳性球菌和厌氧菌感染的重要药物。这类病原体在足部皮肤、软组织及深部感染中常常具有重要意义。红霉素有出色的安全记录，并且对许多微生物仍保持活性，包括一些在足部感染中起作用的微生物。克林霉素和红霉素常被用作青霉素类和头孢菌素类药物的替代品。与红霉素相比，新型大环内酯类药物具有相似的抗菌谱、改善的药代动力学参数以及更好的组织穿透力。随着新的微生物成为临床问题，新型大环内酯类药物可能发挥治疗作用。
