Chen Allen C, Petrylak Daniel P
Department of Medicine, College of Physicians and Surgeons, Columbia University, 177 Fort Washington Avenue, MHB 6-435, New York, NY 10032, USA.
Curr Urol Rep. 2005 May;6(3):210-6. doi: 10.1007/s11934-005-0009-2.
Androgen-deprivation therapy (ADT) is indicated for the treatment of metastatic prostate cancer and locally advanced disease. In addition to sexual side effects, long-term ADT results in several other changes, including hot flashes; gynecomastia; changes in body composition, metabolism, and the cardiovascular system; osteoporosis; anemia; psychiatric and cognitive problems; and fatigue and diminished quality of life. This review discusses these complications of ADT and treatments aimed at reducing them. It is important for clinicians to anticipate these effects and to initiate measures to prevent or minimize them in order to maintain quality of life in prostate cancer survivors.
雄激素剥夺疗法（ADT）适用于转移性前列腺癌和局部晚期疾病的治疗。除了性功能副作用外，长期ADT还会导致其他一些变化，包括潮热；男性乳房发育；身体成分、代谢和心血管系统的改变；骨质疏松；贫血；精神和认知问题；以及疲劳和生活质量下降。本综述讨论了ADT的这些并发症以及旨在减少这些并发症的治疗方法。临床医生必须预见到这些影响，并开始采取措施预防或尽量减少这些影响，以维持前列腺癌幸存者的生活质量。
