Ishida Hisahito, Shirayama Yukihiko, Iwata Masaaki, Kawahara Ryuzou
Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Japan.
Brain Res. 2005 Jun 7;1046(1-2):239-43. doi: 10.1016/j.brainres.2005.04.007.
Learned helplessness, but not immobilization stress, decreased the numbers of neuropeptide Y (NPY)-positive cells (interneuron), but not calcitonin gene-related peptide (CGRP)-positive cells (mossy cell), in the hilus of the hippocampus. Subchronic treatment of learned helplessness rats, but not naive rats, with imipramine ameliorated the decrease in the number of NPY-positive cells. Therefore, NPY-positive cells in the hippocampus may contribute to depression.
