咔唑衍生物作为PPARα/γ双重激动剂和抗氧化剂的设计、合成与评价
Design, synthesis and evaluation of carbazole derivatives as PPAR alpha/gamma dual agonists and antioxidants.
作者信息
Kumar Rakesh, Ramachandran Uma, Srinivasan Krishnamoorthy, Ramarao Poduri, Raichur Suryaprakash, Chakrabarti Ranjan
机构信息
Department of Pharmaceutical Technology, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar 160 062, India.
出版信息
Bioorg Med Chem. 2005 Jul 1;13(13):4279-90. doi: 10.1016/j.bmc.2005.04.018.
A series of hydroxycarbazole derivatives were synthesized and evaluated for PPAR alpha/gamma dual agonist as well as antioxidant activities. While most compounds showed good antioxidant activity, some compounds were identified as potential PPAR alpha/gamma dual agonists as well. Compounds 10a and 16 were found to be active in animal studies.
合成了一系列羟基咔唑衍生物，并对其作为过氧化物酶体增殖物激活受体α/γ双重激动剂的活性以及抗氧化活性进行了评估。虽然大多数化合物表现出良好的抗氧化活性，但也有一些化合物被鉴定为潜在的过氧化物酶体增殖物激活受体α/γ双重激动剂。化合物10a和16在动物研究中被发现具有活性。
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