Tedeschi Candice A, Rubin Mary, Krumholz Burton A
CDC DES Education Project, Great Neck, NY, USA.
J Low Genit Tract Dis. 2005 Jan;9(1):11-8. doi: 10.1097/00128360-200501000-00004.
Diethylstilbestrol (DES), a nonsteroidal estrogen, was widely used in the United States from 1940 through 1971 to prevent pregnancy loss. In the late 1960s, an association was made with an increased incidence of clear cell adenocarcinoma in young women exposed in utero to DES. Additional study of these women over the next 35 years has shown an increased risk of other health problems including intraepithelial neoplasia, ectopic pregnancy, first trimester spontaneous abortion and second trimester pregnancy loss. The National Institutes of Health continues to fund studies to follow cohorts of DES-exposed mothers, daughters, sons and third generation children. The Centers for Disease Control have conducted a large DES Education Project and have established guidelines for management. The following six cases studies illustrate common problems seen in DES exposed daughters and management of problems encountered.
己烯雌酚（DES）是一种非甾体雌激素，在1940年至1971年间在美国被广泛用于预防流产。20世纪60年代末，人们发现子宫内接触过DES的年轻女性患透明细胞腺癌的发病率有所增加。在接下来的35年里，对这些女性的进一步研究表明，她们患其他健康问题的风险也有所增加，包括上皮内瘤变、宫外孕、孕早期自然流产和孕中期流产。美国国立卫生研究院继续资助对接触过DES的母亲、女儿、儿子和第三代儿童队列的研究。疾病控制中心开展了一项大型DES教育项目，并制定了管理指南。以下六个案例研究说明了DES暴露女儿中常见的问题以及所遇到问题的管理方法。
