Pitulescu M, Kessel M, Luo L
Research Group Developmental Biology, Department of Molecular Cell Biology, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
Cell Mol Life Sci. 2005 Jul;62(13):1425-33. doi: 10.1007/s00018-005-4553-1.
Geminin is a multifunctional protein. After DNA replication is initiated during a cell cycle, geminin binds to Cdt1, one of the key DNA replication licensing factors. This highly regulated interaction sequestrates Cdt1, thus preventing DNA rereplication in the same cell cycle. In addition, geminin directly interacts with Six3 and Hox homeodomain proteins during embryogenesis and inhibits their functions. The regulation of Hox function by geminin also involves a transient association with the Hox repressive Polycomb complex. The functions of geminin to obstruct key molecules of both cell proliferation and embryonic development suggest a competitive coordination of these two processes.
Geminin是一种多功能蛋白质。在细胞周期中DNA复制启动后，Geminin与关键的DNA复制许可因子之一Cdt1结合。这种受到高度调控的相互作用隔离了Cdt1，从而防止在同一细胞周期中DNA重新复制。此外，在胚胎发生过程中，Geminin直接与Six3和Hox同源结构域蛋白相互作用并抑制它们的功能。Geminin对Hox功能的调控还涉及与Hox抑制性多梳复合体的短暂结合。Geminin对细胞增殖和胚胎发育关键分子的阻碍作用表明这两个过程存在竞争性协调。
