Zufall F
Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201-1509, USA.
Naunyn Schmiedebergs Arch Pharmacol. 2005 Apr;371(4):245-50. doi: 10.1007/s00210-005-1028-8.
The mammalian vomeronasal organ (VNO) has emerged as an excellent model to investigate the signaling mechanisms, mode of activation, biological function, and molecular evolution of transient receptor potential (TRP) channels in real neurons and real physiological systems. TRPC2, a member of the canonical TRPC subfamily, is highly localized to the dendritic tip of vomeronasal sensory neurons. Targeted deletion of the TRPC2 gene has established that TRPC2 plays a fundamental role in the detection of pheromonal signals by the VNO. TRPC2-deficient mice exhibit striking behavioral defects in the regulation of sexual and social behaviors. A novel Ca(2+)-permeable, diacylglycerol-activated cation channel found at the dendritic tip of vomeronasal neurons is severely defective in TRPC2 mutants, providing the first clear example of native diacylglycerol-gated cation channels in the mammalian nervous system. The TRPC2 gene has become an important marker for the evolution of VNO-dependent pheromone signaling in primates.
哺乳动物犁鼻器（VNO）已成为一个出色的模型，用于研究瞬时受体电位（TRP）通道在真实神经元和真实生理系统中的信号传导机制、激活模式、生物学功能及分子进化。TRPC2是典型TRPC亚家族的成员，高度定位于犁鼻感觉神经元的树突尖端。TRPC2基因的靶向缺失已证实，TRPC2在VNO检测信息素信号中起基本作用。TRPC2基因缺陷的小鼠在性行为和社会行为调节方面表现出明显的行为缺陷。在犁鼻神经元树突尖端发现的一种新型钙通透、二酰基甘油激活的阳离子通道在TRPC2突变体中存在严重缺陷，这为哺乳动物神经系统中天然二酰基甘油门控阳离子通道提供了首个明确实例。TRPC2基因已成为灵长类动物中依赖VNO的信息素信号进化的重要标志。
