Groschner Klaus, Rosker Christian
Institute of Pharmaceutical Sciences, Pharmacology and Toxicology, Karl-Franzens-University of Graz, Universitätsplatz 2, 8010, Graz, Austria.
Naunyn Schmiedebergs Arch Pharmacol. 2005 Apr;371(4):251-6. doi: 10.1007/s00210-005-1054-6.
Transient receptor potential (TRP) proteins have been recognized as sensors for a wide variety of external and internal signals involved in maintenance of cellular homeostasis and control of physiological functions. Evidence of a striking versatility in terms of signal integration and transduction has been reported for members of the canonical (or classical) TRP subfamily (TRPCs). TRPC species are cation channel subunits and emerge as multifunctional signal transduction molecules that are able to function as components of divergent signalplexes. Results obtained in heterologous expression systems suggest TRPC3 as a paradigm of multifunctional signal transduction by a cation channel protein. TRPC3 serves cellular Ca(2+) signaling by multiple mechanisms and may control a variety of distinct physiological functions. In this review, we summarize current knowledge on the properties and possible signaling partners of TRPC3, and discuss the role of TRPC3 channel proteins in cellular signaling networks.
瞬时受体电位（TRP）蛋白已被公认为是多种外部和内部信号的传感器，这些信号参与细胞稳态的维持和生理功能的调控。关于典型（或经典）TRP亚家族（TRPCs）成员在信号整合和转导方面具有显著多功能性的证据已有报道。TRPC种类是阳离子通道亚基，作为多功能信号转导分子出现，能够作为不同信号复合体的组成部分发挥作用。在异源表达系统中获得的结果表明，TRPC3是阳离子通道蛋白进行多功能信号转导的一个范例。TRPC3通过多种机制参与细胞钙（Ca2+）信号传导，并可能控制多种不同的生理功能。在本综述中，我们总结了关于TRPC3的特性和可能的信号传导伙伴的当前知识，并讨论了TRPC3通道蛋白在细胞信号网络中的作用。
