[环氧化酶-2在子宫内膜异位症中的表达]

[Expression of cylooxygenase-2 in endometriosis].

作者信息

Fan Hong, Fang Xiao-ling

机构信息

Department of Gynecology and Obstetrics, Second Xiangya Hospital, Central South University, Changsha, China.

出版信息

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Feb;30(1):92-5.

PMID:15871199

Abstract

OBJECTIVE

To investigate the expression of cyclooxygense-2 (COX-2) in eutopic and ectopic endometrium in ovarian endometriosis.

METHODS

Thirty patients with ovrian endometriosis, 10 with ovarian chocolate cysts and 27 normal controls were enrolled it determine the expression of COX-2 immunohistochemically in eutopic or ectopic endometrium or healthy endometrial tissues.

RESULTS

The immunoreactivities of COX-2 were found in epithelial cells and stromal cells in eutopic endometrium. The expression of COX-2 in the epithelial cells in the secretory phase was higher than that in the proliferative phase in the control group and ovarian endometriosis group (P <0. 05). But the expression of COX-2 in stromal cells in the control group and ovarian endometriosis group showed no cyclic changes throughout the menstrual cycle (P > 0. 05). The expression of COX-2 in eutopic and ectopic endometrium in the ovarian endometriosis group was higher than that in the control group (P <0. 05) , hut we did not find significant difference between the eutopic and ectopic endometrium in the ovarian endometriosis group (P > 0. 05).

CONCLUSION

The increased COX-2 expression in eutopic and ectopic endometrium in ovarian endometriosis may he related to its pathology.

摘要

目的

探讨环氧化酶-2（COX-2）在卵巢子宫内膜异位症在位及异位内膜中的表达。

方法

选取30例卵巢子宫内膜异位症患者、10例卵巢巧克力囊肿患者及27例正常对照者，采用免疫组织化学法检测在位或异位内膜及正常子宫内膜组织中COX-2的表达。

结果

在位内膜的上皮细胞和间质细胞中均有COX-2免疫反应性。对照组和卵巢子宫内膜异位症组中，分泌期上皮细胞COX-2的表达高于增殖期（P<0.05）。但对照组和卵巢子宫内膜异位症组间质细胞COX-2的表达在整个月经周期中无周期性变化（P>0.05）。卵巢子宫内膜异位症组在位及异位内膜中COX-2的表达高于对照组（P<0.05），但卵巢子宫内膜异位症组在位与异位内膜之间未发现显著差异（P>0.05）。