Gastric pseudolymphoma. Not necessarily a benign lesion.

Gastric pseudolymphoma is thought to be a benign process. This report documents the malignant behavior of a gastric pseudolymphoma that was thought to be benign until a distant malignant B-cell lymphoma was demonstrated. Subsequent evaluation traced the B-cell lymphoma back to the gastric "pseudolymphoma." This finding stresses the relationship between gastric pseudolymphoma and gastric lymphoma, and the malignant potential of gastric pseudolymphoma. Multimodal tissue evaluation using histology, immunohistochemistry, and flow cytometry is essential. Surgical resection is the primary therapy for gastric pseudolymphoma.