非甾体抗炎药、甲氨蝶呤或类固醇治疗幼年特发性关节炎对健康相关生活质量的影响。
The impact on health-related quality of life from non-steroidal anti-inflammatory drugs, methotrexate, or steroids in treatment for juvenile idiopathic arthritis.
作者信息
Riddle Russ, Ryser Christina N, Morton Anne A, Sampson J D, Browne Richard H, Punaro Marilynn G, Gatchel Robert J
机构信息
Department of Psychology, Texas Scottish Rite Hospital for Children, 2222 Welborn, Dallas, Texas 75219, USA.
出版信息
J Pediatr Psychol. 2006 Apr;31(3):262-71. doi: 10.1093/jpepsy/jsj014. Epub 2005 May 4.
OBJECTIVE
To assess and compare the impact of medication treatments on health-related quality of life (HRQOL), family function, and medical status in children with juvenile idiopathic arthritis (JIA).
METHODS
Fifty-seven children diagnosed with JIA were assessed by a pediatric rheumatologist and placed into one of three treatment groups: (1) non-steroidal anti-inflammatory; (2) methotrexate; or (3) steroids via IV methylprednisolone. Questionnaires were administered at baseline and 4-month follow-up. The attending pediatric rheumatologist provided additional medical information.
RESULTS
Data document the impact of JIA on HRQOL, particularly on physical and pain domains. Steroid patients experienced improved HRQOL at follow-up relative to other groups, despite reporting more problems with side effects.
CONCLUSION
These results demonstrate positive benefits of steroids in treating JIA children, despite the greatest incidence of adverse side effects.
目的
评估并比较药物治疗对幼年特发性关节炎（JIA）患儿健康相关生活质量（HRQOL）、家庭功能和医疗状况的影响。
方法
57名被诊断为JIA的儿童由一名儿科风湿病学家进行评估，并被分为三个治疗组之一：（1）非甾体抗炎药组；（2）甲氨蝶呤组；或（3）静脉注射甲基泼尼松龙的类固醇组。在基线和4个月随访时进行问卷调查。主治儿科风湿病学家提供了额外的医疗信息。
结果
数据记录了JIA对HRQOL的影响，尤其是对身体和疼痛领域的影响。尽管类固醇治疗组报告的副作用问题更多，但与其他组相比，该组患者在随访时的HRQOL有所改善。
结论
这些结果表明，尽管类固醇治疗的副作用发生率最高，但在治疗JIA患儿方面具有积极益处。
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