Shulgina Galina I
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117465 Moscow, Butlerova 5A, Russia.
Span J Psychol. 2005 May;8(1):86-99. doi: 10.1017/s1138741600004996.
The experiments in conscious non-immobilized rabbits showed that cessation of the reactions without reinforcement (elaboration of the internal inhibition) is accompanied by an enhanced phasic state, by alternation of activation and inhibition of neuron firing, and by the corresponding slow potential oscillation (SPO). These changes can be either localized, predominantly in the structures of conditioned stimulus, or, under enhancement of the inhibitory state, generalized in the brain structures. On the basis of our experience and published data, it is concluded that the above event results from relative enhancement of the inhibitory hyperpolarizing processes due to increase in reactivity of the inhibitory systems to stimulus, which acquires inhibitory properties during learning. Changes in the excitability and reactivity of neuron populations appearing during enhancement of the hyperpolarizing inhibition, and differing in the various brain structures, play an active role in the execution of the main function of the internal inhibition: limitation of excitation transmission to the effectors. An inhibitory mediator gamma aminobutyric acid (GABA) is of great importance in inhibiting the excitation in response to the stimulus which lost its biological significance. These experimental data and their interpretation in the light of published data give the basis for the development of the hyperpolarization theory of internal inhibition.
在清醒、未固定的兔子身上进行的实验表明，无强化反应的停止（内抑制的形成）伴随着相位状态增强、神经元放电的激活与抑制交替，以及相应的慢电位振荡（SPO）。这些变化既可以局限于条件刺激结构中，主要是在条件刺激结构中，也可以在抑制状态增强时，在脑结构中广泛存在。根据我们的经验和已发表的数据得出结论，上述事件是由于抑制系统对刺激的反应性增加，导致抑制性超极化过程相对增强所致，而刺激在学习过程中获得了抑制特性。在超极化抑制增强过程中出现的、在不同脑结构中有所不同的神经元群体兴奋性和反应性变化，在执行内抑制的主要功能：限制兴奋向效应器的传递中发挥着积极作用。抑制性介质γ-氨基丁酸（GABA）在抑制对失去生物学意义的刺激的兴奋方面具有重要作用。这些实验数据及其根据已发表数据的解释为内抑制的超极化理论的发展提供了基础。
