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心房颤动消融术

Atrial fibrillation ablation.

作者信息

Pappone Carlo, Augello Giuseppe, Santinelli Vincenzo

机构信息

Electrophysiology and Cardiac Pacing Unit, Department of Cardiology, San Raffaele University Hospital, Milan, Italy.

出版信息

Ital Heart J. 2005 Mar;6(3):190-9.

Abstract

Radiofrequency catheter ablation is currently used widely and successfully to treat a variety of arrhythmias, and ablation for atrial fibrillation represents the frontier of arrhythmia research. Development in many areas will offer to the electrophysiologic community a more rational and effective background upon which select patients for ablation and identify the optimal ablative strategy. Among mechanisms recognized for having a role in atrial fibrillation stay pulmonary vein focal triggers, rotor at the pulmonary vein-left atrial junction, a critical mass to sustain fibrillatory conduction and vagal ganglia. The latter represents the frontier of research as with new technologies based on magnetic resonance imaging they could be easily and specifically identified and targeted for ablation. It is fundamental that both CARTO and NavX systems are currently investigating integration with magnetic resonance imaging to reconstruct the left atrium. Furthermore a learning curve effect can be abated with the use of new systems for the remote control of the catheter such as stereotaxis. In the last decade, we empirically devised a technique that is both safe and effective for curing atrial fibrillation. Briefly, using a three-dimensional mapping system, either CARTO or NavX system, we reconstruct the left atrium and the pulmonary ostia; thereafter circumferential ablation lines are normally created starting at the lateral mitral annulus and withdrawing posterior then anterior to the left-sided pulmonary veins, passing between the left superior pulmonary vein and the left atrial appendage before completing the circumferential line on the posterior wall of the left atrium. The right pulmonary veins are isolated in a similar fashion, and then a posterior line connecting the two circumferential lines on the roof is performed to reduce the risk of macroreentrant atrial tachycardias. The endpoint for circumferential ablation is a > 70-90% reduction in voltage within the isolated regions. In this article we sought to describe critical methodological aspects of our techniques along with future implementation with new technologies and to summarize our published clinical experience on the most prestigious journals.

摘要

射频导管消融目前已被广泛且成功地用于治疗多种心律失常,而房颤消融代表着心律失常研究的前沿领域。许多领域的发展将为电生理学界提供一个更合理、有效的背景,以便在此基础上选择适合消融的患者并确定最佳消融策略。在被认为与房颤发病机制有关的因素中,包括肺静脉局灶性触发灶、肺静脉 - 左心房交界处的转子、维持颤动传导的临界质量以及迷走神经节。后者是研究的前沿领域,因为借助基于磁共振成像的新技术,它们能够被轻松、准确地识别并作为消融靶点。至关重要的是,CARTO系统和NavX系统目前都在研究与磁共振成像的整合,以重建左心房。此外,使用诸如立体定向等新型导管遥控系统,可以减轻学习曲线效应。在过去十年中,我们凭经验设计了一种治疗房颤既安全又有效的技术。简要来说,使用三维标测系统,即CARTO系统或NavX系统,我们重建左心房和肺静脉口;此后,通常从二尖瓣环外侧开始创建环形消融线,向后回撤,然后向前至左侧肺静脉,在左上肺静脉和左心耳之间穿过,最后在左心房后壁完成环形线。以类似方式隔离右肺静脉,然后在顶部连接两条环形线的后线,以降低大折返性房性心动过速的风险。环形消融的终点是隔离区域内电压降低>70 - 90%。在本文中,我们试图描述我们技术的关键方法学方面以及新技术的未来应用,并总结我们在最具声望的期刊上发表的临床经验。

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