Fan Li-li, Ma Jun, Wang Ya-fang, Ruan Ying-mao, Zeng Xian-ke
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Yao Xue Xue Bao. 2005 Feb;40(2):122-6.
To study the therapeutic effects of oxyphenamone, a novel inodilator, on myocardial ischemia.
The cardiac hemodynamic variables in cats with acute myocardial infarction induced by occlusion of the left anterior descending coronary artery (LAD) were recorded with a physiological polygraph and electromagnetic flowmeter. A model of myocardial necrosis induced by subcutaneous injection of isoproterenol was used for evaluating the effects of drugs on myocardial enzymes and morphological change.
Intravenous injection of oxyphenamone (2 - 8 mg x kg(-1)) dose-dependently decreased heart rate, mean arterial pressure, vascular resistance and the parameters of myocardial oxygen consumption (tension time index, TTI) in cats with myocardial infarction. It increased myocardial contractile force and cardiac output transiently but showed no influence on the left ventricular pressure and cardiac work. The changes of myocardial morphology, creatine phosphate kinase (CPK), malodialdehyde (MDA) and serum glutamic-oxaloacetic transaminase (GOT) induced by isoproterenol in rats were diminished by intraperitoneal injection of oxyphenamone (4 - 8 mg x kg(-1)).
By the examination of the cardiac hemodynamics, myocardial enzymes and morphology, it showed that the myocardial damage induced by ischemia or beta-agonist can be antagonized markedly by oxyphenamone, indicating that oxyphenamone may be beneficial for the treatment of myocardial infarction.
研究新型正性肌力扩血管药奥昔芬胺对心肌缺血的治疗作用。
用生理记录仪和电磁流量计记录冠状动脉左前降支（LAD）闭塞诱导的急性心肌梗死猫的心脏血流动力学变量。皮下注射异丙肾上腺素诱导的心肌坏死模型用于评估药物对心肌酶和形态变化的影响。
静脉注射奥昔芬胺（2 - 8 mg·kg⁻¹）可使心肌梗死猫的心率、平均动脉压、血管阻力和心肌耗氧量参数（张力时间指数，TTI）剂量依赖性降低。它可短暂增加心肌收缩力和心输出量，但对左心室压力和心脏作功无影响。腹腔注射奥昔芬胺（4 - 8 mg·kg⁻¹）可减轻异丙肾上腺素诱导的大鼠心肌形态、肌酸磷酸激酶（CPK）、丙二醛（MDA）和血清谷草转氨酶（GOT）的变化。
通过对心脏血流动力学、心肌酶和形态的检查，表明奥昔芬胺可明显拮抗缺血或β-激动剂诱导的心肌损伤，提示奥昔芬胺可能对心肌梗死治疗有益。
