Papapetropoulos S, Lieberman A, Gonzalez J, Mash D C
Department of Neurology, School of Medicine, University of Miami, Miami, FL, USA.
Acta Neurol Scand. 2005 Jun;111(6):353-9. doi: 10.1111/j.1600-0404.2005.00411.x.
Patients with clinical and pathological diagnosis of Parkinson's disease (PD) may, at death, also be found to have the pathological changes of Alzheimer's disease (AD). With this study we aim to determine the influence of AD pathology on the clinical phenotype of PD.
We studied 64 patients who donated their brains to the University of Miami Brain Endowment Bank(TM) and fulfilled the clinical and pathological criteria for PD. For the evaluation of AD pathology we used the CERAD criteria. Dementia was diagnosed, in life, also using standard criteria. Case histories were abstracted and reviewed by one investigator (SP) who then made comparisons between patients.
Patients with AD pathology (PD-AD) were older both at the time of diagnosis and death. The presence of AD pathology did not seem to influence disease duration in our cohort of PD patients. As expected there was a clear relation between AD pathology and dementia but not all PD-AD patients were demented. Psychosis and depression were also found to be more prevalent in the PD-AD patients. In the comparison between demented and non-demented PD-AD patients dementia was more likely to appear in patients with PD and definite criteria for AD.
Apart from dementia AD pathology seems to be associated with a number of other clinical characteristics of PD.
临床及病理诊断为帕金森病（PD）的患者在死亡时，也可能被发现存在阿尔茨海默病（AD）的病理改变。通过本研究，我们旨在确定AD病理对PD临床表型的影响。
我们研究了64名将大脑捐赠给迈阿密大学脑捐赠库（TM）且符合PD临床及病理标准的患者。为评估AD病理，我们采用了CERAD标准。生前痴呆的诊断也采用标准标准。由一名研究者（SP）提取并审查病例史，然后对患者进行比较。
有AD病理改变的患者（PD-AD）在诊断时和死亡时年龄更大。在我们的PD患者队列中，AD病理改变的存在似乎并未影响疾病持续时间。正如预期的那样，AD病理与痴呆之间存在明显关联，但并非所有PD-AD患者都患有痴呆。还发现精神病和抑郁症在PD-AD患者中更为普遍。在痴呆和非痴呆的PD-AD患者之间的比较中，痴呆更可能出现在符合AD明确标准的PD患者中。
除痴呆外，AD病理似乎还与PD的许多其他临床特征相关。
