Dus Santos María José, Wigdorovitz Andrés
Veterinary and Agronomy Research Center, INTA-Castelar, Buenos Aires, Argentina.
Immunol Cell Biol. 2005 Jun;83(3):229-38. doi: 10.1111/j.1440-1711.2005.01338.x.
The expression of antigens in transgenic plants has been increasingly used in the development of experimental vaccines, particularly oriented to the development of edible vaccines. Hence, this technology becomes highly suitable to express immunogenic proteins from pathogens. Foot and mouth disease virus, bovine rotavirus and bovine viral diarrhoea virus are considered to be the most important causative agents of economic loss of cattle production in Argentina, and they are thus optimal candidates for alternative means of immunization. Here, we present a review of our results corresponding to the expression of immunogenic proteins from these three viruses in alfalfa transgenic plants, and we discuss the possibility of using them for the development of plant-based vaccines.
抗原在转基因植物中的表达已越来越多地用于实验疫苗的开发，尤其是用于可食用疫苗的开发。因此，这项技术非常适合表达病原体的免疫原性蛋白。口蹄疫病毒、牛轮状病毒和牛病毒性腹泻病毒被认为是阿根廷牛生产经济损失的最重要致病因子，因此它们是替代免疫方法的最佳候选者。在此，我们综述了我们在苜蓿转基因植物中表达这三种病毒免疫原性蛋白的相关结果，并讨论了将它们用于开发植物源疫苗的可能性。
