Shin Jacqueline C, Aparicio Paul, Ivry Richard B
Department of Psychology, University of Virginia, United States.
Brain Cogn. 2005 Jun;58(1):75-83. doi: 10.1016/j.bandc.2004.09.015. Epub 2004 Dec 2.
Parkinson's patients have been found to be impaired in learning movement sequences. In the current study, patients with unilateral basal ganglia lesions due to stroke were tested on a serial reaction time task in which responses were based on the spatial location of each stimulus. The spatial locations either followed a fixed sequence or were selected at random, with learning operationalized as the difference in reaction time between these two conditions. In addition, three response-to-stimulus intervals were used, and these either followed a fixed sequence or were randomized. Compared to control participants, the patients showed normal learning of the spatial and temporal sequences, as well as normal cross-dimensional learning. This was true for performance with either the contralesional or ipsilesional hand. Sequence learning was not correlated with maximum tapping rate, a simple measure of motor impairment. These results raise questions concerning the use of Parkinson's disease as a model for studying basal ganglia dysfunction.
帕金森病患者已被发现存在学习运动序列方面的障碍。在当前研究中，对因中风导致单侧基底神经节损伤的患者进行了一项序列反应时任务测试，其中反应基于每个刺激的空间位置。空间位置要么遵循固定序列，要么随机选择，学习被定义为这两种条件下反应时的差异。此外，使用了三种刺激 - 反应间隔，这些间隔要么遵循固定序列，要么随机化。与对照组参与者相比，患者在空间和时间序列学习以及跨维度学习方面表现正常。使用对侧手或同侧手进行操作时均如此。序列学习与最大敲击速率（一种简单的运动损伤测量指标）无关。这些结果引发了关于将帕金森病用作研究基底神经节功能障碍模型的质疑。
