Calissendorff Jan, Danielsson Olle, Brismar Kerstin, Röjdmark Sven
Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Stockholm, Sweden.
Eur J Endocrinol. 2005 May;152(5):743-7. doi: 10.1530/eje.1.01905.
Human appetite is stimulated by alcohol but the underlying mechanism is unknown. It is possible that hunger-stimulating hormones are mediators of this effect of alcohol. Ghrelin stimulates hunger, but how alcohol affects human ghrelin secretion has never been studied before.
To investigate whether alcohol ingestion exerts an acute influence on serum ghrelin concentrations in healthy subjects.
Eight healthy non-obese subjects participated in the study. All were investigated on two occasions (experiments A and B). Alcohol (0.55 g ethanol/kg body weight) was ingested in experiment A, and drinking-water in experiment B. Venous blood was collected before, and 30 and 60 min after consumption of the drinks. Serum concentrations of ghrelin, cortisol and ethanol were determined and neuropeptide Y (NPY) concentrations were determined in plasma.
Alcohol lowered the ghrelin level by 13.9+/-5.0% at 30 min and by 17.5+/-2.6% at 60 min, in contrast to drinking-water which was without significant effect. Serum levels of cortisol and insulin were similar after alcohol and water as was plasma NPY.
Alcohol has an acute inhibitory influence on human ghrelin secretion but no measurable effect on the secretion of NPY and cortisol. Hence, none of these hormones mediate the orexigenic effect of the drug.
酒精可刺激人的食欲，但其潜在机制尚不清楚。饥饿刺激激素可能是酒精这种作用的介导因素。胃饥饿素可刺激饥饿感，但此前从未研究过酒精如何影响人体胃饥饿素的分泌。
研究摄入酒精对健康受试者血清胃饥饿素浓度是否有急性影响。
8名健康非肥胖受试者参与本研究。所有受试者均接受两次检测（实验A和实验B）。实验A中摄入酒精（0.55克乙醇/千克体重），实验B中摄入饮用水。在饮用饮料前、饮用后30分钟和60分钟采集静脉血。测定血清胃饥饿素、皮质醇和乙醇浓度，并测定血浆中神经肽Y（NPY）浓度。
与饮用饮用水无显著影响相比，酒精在30分钟时使胃饥饿素水平降低13.9±5.0%，在60分钟时降低17.5±2.6%。酒精和水摄入后血清皮质醇和胰岛素水平相似，血浆NPY水平也相似。
酒精对人体胃饥饿素分泌有急性抑制作用，但对NPY和皮质醇的分泌无明显影响。因此，这些激素均未介导该药物的促食欲作用。
