Nikkanen V, Kresanov I, Mäkinen J, Vuorento T
Department of Obstetrics and Gynaecology, University Central Hospital, Turku, Finland.
Hum Reprod. 1992 Mar;7(3):333-6. doi: 10.1093/oxfordjournals.humrep.a137644.
Attempts have been made to increase the low pregnancy rate in in-vitro fertilization (IVF) cycles by luteal phase support with progesterone or human chorionic gonadotrophin (HCG). Previously, this practice has been inconsistent and the results unclear. The detailed effect of support on the progesterone profile in the luteal phase was assessed by daily salivary progesterone measurements in non-conception IVF cycles. The comparison of HCG and progesterone support in two different stimulation protocols showed that the profile of luteal progesterone concentrations was similar in control cycles and those supported with a vaginal progesterone suppository, showing an early decrease by the fourth luteal day. In cycles supported with multiple doses of HCG, the progesterone profile was normal but slightly increased up to the 9th luteal day subsequently falling to basal levels by the fourteenth luteal day.
人们尝试通过在黄体期使用黄体酮或人绒毛膜促性腺激素（HCG）来提高体外受精（IVF）周期中较低的妊娠率。此前，这种做法并不一致，结果也不明确。通过在未受孕的IVF周期中每日测量唾液中的黄体酮，评估了黄体期支持对黄体酮水平的具体影响。在两种不同的刺激方案中对HCG和黄体酮支持进行比较，结果显示，在对照周期和使用阴道黄体酮栓剂支持的周期中，黄体期黄体酮浓度曲线相似，在黄体期第4天出现早期下降。在使用多剂量HCG支持的周期中，黄体酮曲线正常，但在黄体期第9天之前略有上升，随后在黄体期第14天降至基础水平。
