含片直接激活阿戈斯和克伦普福斯以调节程序性细胞死亡。
Lozenge directly activates argos and klumpfuss to regulate programmed cell death.
作者信息
Wildonger Jill, Sosinsky Alona, Honig Barry, Mann Richard S
机构信息
Center for Neurobiology and Behavior, Howard Hughes Medical Institute, Columbia University Medical School, New York, NY 10032, USA.
出版信息
Genes Dev. 2005 May 1;19(9):1034-9. doi: 10.1101/gad.1298105.
Abstract
We show that reducing the activity of the Drosophila Runx protein Lozenge (Lz) during pupal development causes a decrease in cell death in the eye. We identified Lz-binding sites in introns of argos (aos) and klumpfuss (klu) and demonstrate that these genes are directly activated targets of Lz. Loss of either aos or klu reduces cell death, suggesting that Lz promotes apoptosis at least in part by regulating aos and klu. These results provide novel insights into the control of programmed cell death (PCD) by Lz during Drosophila eye development.
摘要
我们发现，在果蝇蛹期发育过程中降低果蝇Runx蛋白菱形（Lz）的活性会导致眼睛中的细胞死亡减少。我们在argos（aos）和klumpfuss（klu）的内含子中鉴定出Lz结合位点，并证明这些基因是Lz的直接激活靶点。aos或klu的缺失都会减少细胞死亡，这表明Lz至少部分通过调节aos和klu来促进细胞凋亡。这些结果为果蝇眼睛发育过程中Lz对程序性细胞死亡（PCD）的控制提供了新的见解。
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本文引用的文献
1
Developing compound eye in lozenge mutants of Drosophila: lozenge expression in the R7 equivalence group.果蝇菱形突变体中复眼的发育：菱形基因在R7等效组中的表达
Dev Genes Evol. 1997 May;206(8):481-493. doi: 10.1007/s004270050079.
2
A role for wingless in an early pupal cell death event that contributes to patterning the Drosophila eye.无翅基因在早期蛹期细胞死亡事件中的作用，该事件有助于果蝇眼睛的模式形成。
Mech Dev. 2004 Dec;121(12):1523-30. doi: 10.1016/j.mod.2004.07.004.
3
klumpfuss regulates cell death in the Drosophila retina.klumpfuss基因调控果蝇视网膜中的细胞死亡。
Mech Dev. 2004 Jun;121(6):537-46. doi: 10.1016/j.mod.2004.04.008.
4
WT1 gene expression: an excellent tool for monitoring minimal residual disease in 70% of acute myeloid leukaemia patients - results from a single-centre study.WT1基因表达：监测70%急性髓系白血病患者微小残留病的优秀工具——一项单中心研究结果
Br J Haematol. 2004 Jun;125(5):590-600. doi: 10.1111/j.1365-2141.2004.04952.x.
5
Wingless eliminates ommatidia from the edge of the developing eye through activation of apoptosis.无翅蛋白通过激活细胞凋亡，从发育中眼睛的边缘消除小眼。
Development. 2004 May;131(10):2409-18. doi: 10.1242/dev.01104.
6
Regulators of IAP function: coming to grips with the grim reaper.IAP功能的调节因子：直面死神
Curr Opin Cell Biol. 2003 Dec;15(6):717-24. doi: 10.1016/j.ceb.2003.10.002.
7
Homothorax switches function of Drosophila photoreceptors from color to polarized light sensors.同胸蛋白将果蝇光感受器的功能从颜色传感器转变为偏振光传感器。
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Nucleic Acids Res. 2003 Jul 1;31(13):3589-92. doi: 10.1093/nar/gkg544.
9
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Cell Biol Int. 2003;27(4):315-24. doi: 10.1016/s1065-6995(03)00018-0.
10
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