难治性乳糜泻：英夫利昔单抗与免疫调节剂联合治疗可实现缓解

Refractory coeliac disease: remission with infliximab and immunomodulators.

作者信息

Turner Sue M, Moorghen Moorghen, Probert Chris S J

机构信息

Department of Gastroenterology, Bristol Royal Infirmary, Marlborough Street, Bristol, UK.

出版信息

Eur J Gastroenterol Hepatol. 2005 Jun;17(6):667-9. doi: 10.1097/00042737-200506000-00012.

DOI:10.1097/00042737-200506000-00012

PMID:15879730

Abstract

Coeliac disease is a T-cell-mediated enteropathy induced by gluten. A minority of patients who fail to respond to a gluten-free diet may require intervention with immunomodulating drugs. We report a case of refractory coeliac disease where remission was induced by the anti-tumour necrosis factor-alpha antibody infliximab and was maintained with prednisolone and azathioprine.

摘要

乳糜泻是一种由麸质引发的T细胞介导的肠病。少数对无麸质饮食无反应的患者可能需要使用免疫调节药物进行干预。我们报告了一例难治性乳糜泻病例，该病例通过抗肿瘤坏死因子-α抗体英夫利昔单抗诱导缓解，并通过泼尼松龙和硫唑嘌呤维持缓解状态。