Claeys Gina B, Sarma Aruna V, Dunn Rodney L, Zuhlke Kimberly A, Beebe-Dimmer Jennifer, Montie James E, Wojno Kirk J, Schottenfeld David, Cooney Kathleen A
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Prostate. 2005 Sep 15;65(1):83-7. doi: 10.1002/pros.20271.
Both prostate cancer and diabetes mellitus are common diseases in African-American men. High insulin levels and insulin resistance have been implicated in prostate cancer development, which has prompted a recent investigation of a possible role for germline variation in the insulin gene (INS) and prostate cancer risk.
Four hundred sixty-six African-American men with and without prostate cancer from the Flint Men's Health Study were typed for the INS Pst1 genotype using restriction digest and direct sequencing. An association between the Pst1 genotype and prostate cancer was examined using crude and age-adjusted logistic regression models.
African-American men who were homozygous for the INS PstI CC genotype were 1.59 times more likely to be diagnosed with prostate cancer compared to men with the TT or TC genotypes (95% CI = 0.93-2.72). The association appeared stronger among diabetics compared to non-diabetics; however this observation was not statistically significant.
Our study, taken together with the report of Ho et al., suggests that the INS Pst1 CC genotype is associated with prostate cancer risk in African-American men. Germline variation in the INS gene should be more fully explored in multiethnic studies to elucidate the molecular variant(s) associated with prostate carcinogenesis.
前列腺癌和糖尿病在非裔美国男性中都是常见疾病。高胰岛素水平和胰岛素抵抗与前列腺癌的发生有关，这促使最近对胰岛素基因（INS）的种系变异与前列腺癌风险的可能作用进行了调查。
使用限制性酶切和直接测序对弗林特男性健康研究中466名患有和未患有前列腺癌的非裔美国男性进行INS Pst1基因型分型。使用原始和年龄调整后的逻辑回归模型检查Pst1基因型与前列腺癌之间的关联。
与具有TT或TC基因型的男性相比，INS PstI CC基因型纯合的非裔美国男性被诊断患有前列腺癌的可能性高1.59倍（95%置信区间=0.93-2.72）。与非糖尿病患者相比，糖尿病患者中的这种关联似乎更强；然而，这一观察结果在统计学上并不显著。
我们的研究与Ho等人的报告一起表明，INS Pst1 CC基因型与非裔美国男性的前列腺癌风险相关。应在多民族研究中更全面地探索INS基因的种系变异，以阐明与前列腺癌发生相关的分子变异。
