Rinaldo Alessandra, Devaney Kenneth O, Ferlito Alfio
Department of Surgical Sciences, ENT Clinic, University of Udine, Udine, Italy.
Acta Otolaryngol. 2005 Feb;125(2):125-9. doi: 10.1080/00016480410017503-1.
Merkel cell carcinoma (MCC) is an uncommon cutaneous neoplasm which arises in adults with a peak incidence in the sixth and seventh decades. MCC most often arises in the head and neck area and extremities. Among head and neck primary sites, auricular MCC has proven to be rare and only 20 cases have been reported in the literature. Auricular MCC follows the same aggressive course as has been documented for MCC arising elsewhere: the tumor has a propensity for recurring locally and metastasizing to regional lymph nodes and distant sites. Location of MCC in the auricular regions does not appear to confer any survival advantage compared with MCC arising elsewhere. The mainstay of treatment is surgery, with attempts at complete surgical excision being of paramount importance. What role regional node dissection, radiation therapy and chemotherapy may play in the standard treatment of auricular MCC remains to be clearly established.
默克尔细胞癌（MCC）是一种罕见的皮肤肿瘤，多见于成年人，发病高峰在六七十岁。MCC最常发生于头颈部和四肢。在头颈部的原发部位中，耳部MCC已被证实很罕见，文献中仅报道过20例。耳部MCC的病程与其他部位发生的MCC一样具有侵袭性：肿瘤易于局部复发，并转移至区域淋巴结和远处部位。与其他部位发生的MCC相比，耳部MCC的位置似乎并未带来任何生存优势。治疗的主要手段是手术，力求完整切除肿瘤至关重要。区域淋巴结清扫、放射治疗和化疗在耳部MCC的标准治疗中可能发挥何种作用仍有待明确。
