鼻息肉中的糖胺聚糖
Glycosoaminoglycans in nasal polyps.
作者信息
Pawłowska-Góral Katarzyna, Gierek Tatiana, Majzel Krystyna, Wardas Piotr, Wardas Maria
机构信息
Department of General and Analytical Chemistry, Silesian Academy of Medicine, Sosnowiec, Poland.
出版信息
Acta Otolaryngol. 2005 Feb;125(2):177-9. doi: 10.1080/00016480410017116.
CONCLUSION
The qualitative and quantitative compositions of GAGs were comparable in all the polyps examined.
OBJECTIVE
Glycosoaminoglycans (GAGs) are an integral component of proteoglycans, which are constituents of connective tissue. The qualitative and quantitative compositions of GAGs occurring in proteoglycans determine their biological role. In this work, individual fractions of GAGs occurring in nasal polyps were isolated and estimated.
MATERIAL AND METHODS
Polyps were obtained over a 2-year period from 31 patients (18 males, 13 females; age range 28-70 years) who underwent polypectomy and evaluated using routine histopathology.
RESULTS
The amount of hyaluronic acid in nasal polyps was high, the amounts of dermatane sulphate and chondroitine-6-sulphate were slightly lower and the amounts of chondroitine-4-sulphate, heparin, heparan sulphate and keratan sulphate were the lowest.
结论
在所检查的所有息肉中，糖胺聚糖的定性和定量组成具有可比性。
目的
糖胺聚糖（GAGs）是蛋白聚糖的一个组成部分，而蛋白聚糖是结缔组织的成分。蛋白聚糖中存在的糖胺聚糖的定性和定量组成决定了它们的生物学作用。在这项研究中，对鼻息肉中存在的糖胺聚糖的各个组分进行了分离和评估。
材料与方法
在两年时间里，从31例接受息肉切除术的患者（18例男性，13例女性；年龄范围28 - 70岁）中获取息肉，并使用常规组织病理学进行评估。
结果
鼻息肉中透明质酸的含量较高，硫酸皮肤素和硫酸软骨素-6-硫酸酯的含量略低，硫酸软骨素-4-硫酸酯、肝素、硫酸乙酰肝素和硫酸角质素的含量最低。
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