他克莫司用于环孢素和泼尼松依赖型重症肌无力的长期疗效
Long-term results of tacrolimus in cyclosporine- and prednisone-dependent myasthenia gravis.
作者信息
Ponseti J M, Azem J, Fort J M, López-Cano M, Vilallonga R, Buera M, Cervera C, Armengol M
机构信息
Myasthenia Gravis Unit, Department of Surgery, Hospital General Universitari Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain.
出版信息
Neurology. 2005 May 10;64(9):1641-3. doi: 10.1212/01.WNL.0000160392.32894.6D.
Seventy-nine patients with cyclosporine- and prednisone-dependent myasthenia gravis (MG) after thymectomy received tacrolimus for a mean of 2.5 +/- 0.8 years. Prednisone was withdrawn in all but two patients. Anti-acetylcholine antibodies and MG score for disease severity decreased significantly and muscular strength increased by 39%. Complete stable remission was achieved in 5% of patients and pharmacologic remission in 87.3%. All patients resumed full activities of daily living.
79例胸腺切除术后依赖环孢素和泼尼松的重症肌无力（MG）患者接受了他克莫司治疗，平均治疗时间为2.5±0.8年。除两名患者外，所有患者均停用了泼尼松。抗乙酰胆碱抗体和疾病严重程度的MG评分显著降低，肌肉力量增加了39%。5%的患者实现了完全稳定缓解，87.3%的患者实现了药物缓解。所有患者都恢复了正常的日常生活活动。
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