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重症肌无力的当前治疗方法

Current Treatment of Myasthenia Gravis.

作者信息

Alhaidar Mohammed K, Abumurad Sumayyah, Soliven Betty, Rezania Kourosh

机构信息

Department of Neurology, University of Chicago Medical Center, Chicago, IL 60637, USA.

出版信息

J Clin Med. 2022 Mar 14;11(6):1597. doi: 10.3390/jcm11061597.

Abstract

Myasthenia gravis (MG) is the most extensively studied antibody-mediated disease in humans. Substantial progress has been made in the treatment of MG in the last century, resulting in a change of its natural course from a disease with poor prognosis with a high mortality rate in the early 20th century to a treatable condition with a large proportion of patients attaining very good disease control. This review summarizes the current treatment options for MG, including non-immunosuppressive and immunosuppressive treatments, as well as thymectomy and targeted immunomodulatory drugs.

摘要

重症肌无力(MG)是人类中研究最为广泛的抗体介导性疾病。在上个世纪,重症肌无力的治疗取得了重大进展,使其自然病程发生了改变,从20世纪初预后不良、死亡率高的疾病转变为一种可治疗的疾病,大部分患者能够实现非常良好的疾病控制。本综述总结了目前重症肌无力的治疗选择,包括非免疫抑制和免疫抑制治疗,以及胸腺切除术和靶向免疫调节药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc2/8950430/3f83da5822cb/jcm-11-01597-g001.jpg

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