[我如何通过外用吡美莫司（爱宁达）治疗……特应性皮炎。钙调神经磷酸酶抑制剂的新范例]

[How I treat ... atopic dermatitis by topical pimecrolimus (Elidel). The emerging paradigm of calcineurin inhibitors].

作者信息

Piérard-Franchimont C, Quatresooz P, Piérard G E

机构信息

CHU du Sart Tilman, Service de Dermatopathologie, Liège.

出版信息

Rev Med Liege. 2005 Mar;60(3):136-40.

PMID:15884695

Abstract

Topical calcineurin inhibitors, also called topical immunomodulators or downregulators, represent an innovative class of non-steroidal anti-inflammatory agents. Pimecrolimus 1% cream (Elidel) is one representative drug available for the treatment of atopic dermatitis. Unlike topical steroids, this drug does not affect collagen synthesis and does not alter the dendritic cell functions and the barrier function of the skin.

摘要

局部钙调神经磷酸酶抑制剂，也称为局部免疫调节剂或下调剂，是一类创新的非甾体抗炎药。1%吡美莫司乳膏（爱宁达）是一种可用于治疗特应性皮炎的代表性药物。与局部类固醇不同，该药物不影响胶原蛋白合成，也不会改变皮肤的树突状细胞功能和屏障功能。