[外用米替福新治疗腿部鳞状细胞癌皮肤转移瘤]
[Treatment of cutaneous metastases of a squamous cell carcinoma of the leg with topical miltefosine].
作者信息
Mahieu-Renard L, Richard M-A, Dales J-P, Buscaylet S, Lagrassa S, Grob J-J
机构信息
Service de Dermatologie, Hôpital Sainte-Marguerite, Marseille.
出版信息
Ann Dermatol Venereol. 2005 Apr;132(4):346-8. doi: 10.1016/s0151-9638(05)79280-2.
INTRODUCTION
Miltefosine (Hexadecylphosphocholine) is a chemotherapy, which when applied locally, has demonstrated efficacy in the treatment of cutaneous metastases of breast cancer.
CASE REPORT
A 79 year-old woman developed recurrent in transit cutaneous metastases of a squamous cell carcinoma on her left leg. All lesions completely resolved after topical applications of miltefosine. Tolerance was excellent and the patient remained disease-free 24 months after the end of the treatment.
DISCUSSION
Miltefosine, which might prove to be a simple and effective alternative for the usually heavy treatments proposed, warrants further assessment in this context.
引言
米替福新（十六烷基磷酰胆碱）是一种化疗药物，局部应用时已证明对乳腺癌皮肤转移瘤的治疗有效。
病例报告
一名79岁女性左腿出现复发性鳞状细胞癌皮肤转移。局部应用米替福新后，所有病灶完全消退。耐受性良好，治疗结束24个月后患者仍无疾病复发。
讨论
米替福新可能是一种简单有效的替代方案，可替代通常提出的繁重治疗方法，在此背景下值得进一步评估。
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