Unger C, Peukert M, Sindermann H, Hilgard P, Nagel G, Eibl H
Department of Internal Medicine, University Hospital, Göttingen, Federal Republic of Germany.
Cancer Treat Rev. 1990 Sep;17(2-3):243-6. doi: 10.1016/0305-7372(90)90054-j.
Widespread local recurrence of breast cancer, untreatable by surgery or radiation therapy, can present a serious therapeutic problem predominantly in patients refractory to systemic therapy. In a phase I trial hexadecylphosphocholine, a new agent with high membrane affinity and antineoplastic activity was applied topically to affected skin areas of breast cancer patients. The results provide evidence that hexadecylphosphocholine may be an active agent in the topical treatment of skin metastases.
乳腺癌广泛的局部复发无法通过手术或放射治疗进行处理，这主要在对全身治疗无效的患者中构成严重的治疗难题。在一项I期试验中，将具有高膜亲和力和抗肿瘤活性的新型药物十六烷基磷胆碱局部应用于乳腺癌患者的患肤区域。结果证明十六烷基磷胆碱可能是皮肤转移瘤局部治疗的一种有效药物。
