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[类风湿关节炎新的美国风湿病学会(ARA)标准的临床评估与应用]

[Clinical evaluation and application of new ARA criteria for rheumatoid arthritis].

作者信息

Sagawa A, Nakagawa S

机构信息

Second department of internal medicine, Hokkaido university school of medicine.

出版信息

Nihon Rinsho. 1992 Mar;50(3):473-8.

PMID:1588734
Abstract

At the 51st American Rheumatism Association meeting, a new ARA criteria for rheumatoid arthritis (RA) was proposed. According to this criteria, both the sensitivity and the specificity have improved to 93% and 90%, respectively. We investigated the adequacy of this criteria by applying this to Japanese patients with RA and control subjects with rheumatic diseases, other than RA. By using new criteria the sensitivity was decreased from 89.6% to 85.3% and the specificity was increased from 82.7% to 92.8%. The factors for the decreased sensitivity of the new criteria were 1) morning stiffness which became more than 1 hour, 2) the number of swelling joints increased from one to three and 3) radiologic changes, which were restricted to the hand only. On the other hand, the factors for increased specificity were (1) morning stiffness, (2) deletion of criterion of joint pain and (3) joint swelling. According to the classification tree method, the sensitivity and the specificity were 96.3% and 90.0% respectively in this study. Continued nationwide study on this new criteria, whether this is applicable and useful to classify Japanese patients with RA is necessary.

摘要

在第51届美国风湿病协会会议上,提出了类风湿关节炎(RA)的新美国风湿病协会(ARA)标准。根据该标准,敏感性和特异性分别提高到了93%和90%。我们将此标准应用于日本RA患者以及除RA外的其他风湿性疾病对照受试者,以研究该标准的适用性。使用新标准后,敏感性从89.6%降至85.3%,特异性从82.7%增至92.8%。新标准敏感性降低的因素为:1)晨僵超过1小时;2)肿胀关节数量从1个增加到3个;3)放射学改变,仅局限于手部。另一方面,特异性增加的因素为:(1)晨僵;(2)删除关节疼痛标准;(3)关节肿胀。根据分类树方法,本研究中敏感性和特异性分别为96.3%和90.0%。有必要在全国范围内继续研究这一新标准,看其是否适用于对日本RA患者进行分类以及是否有用。

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