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1987年美国风湿病学会修订标准从一个为药物报销登记的慢性风湿性疾病人群队列中挑选出临床类风湿性关节炎患者。

The ARA 1987 revised criteria select patients with clinical rheumatoid arthritis from a population based cohort of subjects with chronic rheumatic diseases registered for drug reimbursement.

作者信息

Hakala M, Pöllänen R, Nieminen P

机构信息

Päivärinne Hospital, Muhos, Finland.

出版信息

J Rheumatol. 1993 Oct;20(10):1674-8.

PMID:8295178
Abstract

We tested the traditional format of the American Rheumatism Association (ARA) 1987 revised criteria for the classification of rheumatoid arthritis (RA) in a cohort of 220 subjects with drug reimbursement for chronic rheumatic diseases extracted from the National Sickness Insurance Register, in a community of 18,000 people in Finland. One hundred and nine of the 193 who consented to the study both met the new ARA criteria for RA and had disease onset after 16 years of age, giving a cumulative prevalence of 0.8% in the population of 13,300 over 16 years. The disease of 6 of them, however, fulfilled the criteria and clinical picture of some other rheumatic disease. Thus 103 patients had RA as the only diagnosis. The female:male ratio in the 103 patients was 1.7:1. Ninety-one (88%) had seropositivity at some time in their disease and 99 (96%) had erosive joint disease. In most instances the 12 seronegatives had either mild or nontypical RA and only one of them was male. The 103 patients who met the new ARA criteria had significantly more interventions, such as hospitalization, drug treatment and orthopedic surgery, than the subjects (n = 42) who despite a clinician's primary diagnosis of RA did not fulfill the criteria. Thus the new ARA criteria distinguish clinical and severe cases of RA from nonclinical or non-RA cases when applied to a population based cohort of subjects with chronic rheumatic diseases registered for drug reimbursement.

摘要

我们在芬兰一个拥有18000人的社区中,对从国家疾病保险登记处提取的220名患有慢性风湿性疾病且有药物报销资格的受试者队列,测试了美国风湿病协会(ARA)1987年修订的类风湿关节炎(RA)分类标准。在同意参与研究的193名受试者中,有109名既符合新的ARA类风湿关节炎标准,且发病年龄在16岁之后,在13300名16岁以上的人群中累积患病率为0.8%。然而,其中6人的疾病符合其他一些风湿性疾病的标准和临床表现。因此,有103名患者的唯一诊断为类风湿关节炎。这103名患者中女性与男性的比例为1.7:1。91名(88%)在病程中的某些时候血清呈阳性,99名(96%)有侵蚀性关节疾病。在大多数情况下,12名血清阴性患者患有轻度或非典型类风湿关节炎,其中只有1名男性。符合新ARA标准的103名患者比那些尽管临床医生初步诊断为类风湿关节炎但不符合标准的受试者(n = 42)有更多的干预措施,如住院、药物治疗和骨科手术。因此,当应用于基于人群的、登记有慢性风湿性疾病且有药物报销资格的受试者队列时,新的ARA标准能够区分类风湿关节炎的临床和严重病例与非临床或非类风湿关节炎病例。

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