Mohseni Pedram, Najafi Khalil
Center for Wireless Integrated MicroSystems, Electrical Engineering and Computer Science Department, University of Michigan, Ann Arbor, MI 48109-2122, USA.
IEEE Trans Biomed Eng. 2005 May;52(5):938-43. doi: 10.1109/TBME.2005.845369.
This paper presents a low-phase-noise, hybrid LC-tank, analog frequency modulator for wireless biotelemetry employing on-chip NMOS varactors in the inversion region as the frequency tuning element. We demonstrate that a correct estimate for the destination signal-to-noise ratio, which quantifies the quality of the wirelessly received signal in a frequency-modulated biotelemetry system, is only achieved after taking into account the large-signal oscillation effect on the tank varactor. A prototype chip is fabricated using AMI 1.5-microm double-poly double-metal n-well CMOS process, and exhibits a measured gain factor of 1.21 MHz/V in the mid-range of the tuning voltage and a phase noise of -88.6 dBc/Hz at 10-kHz offset from the 95.1-MHz carrier while dissipating 1.48 mW from a 3 V power supply leading to a figure of merit (FOM) of -166.5 dBc/Hz. The VCO is successfully interfaced with a penetrating silicon microelectrode with 700 microm2 iridium recording sites for wireless in vitro recording of a 50 Hz simulated normal sinus rhythm signal from saline over a distance of approximately 0.25 m. Given a typical gain of approximately 40 dB for fully integrated front-end bioamplifiers, a wireless recording microsystem employing this VCO would be capable of detecting input biopotentials down to the submilivolt range.
本文提出了一种用于无线生物遥测的低相位噪声、混合LC振荡回路模拟频率调制器,该调制器采用处于反型区的片上NMOS变容二极管作为频率调谐元件。我们证明,只有在考虑到振荡回路变容二极管上的大信号振荡效应之后,才能对目标信噪比进行正确估计,该信噪比量化了调频生物遥测系统中无线接收信号的质量。采用AMI 1.5微米双多晶硅双金属n阱CMOS工艺制作了一个原型芯片,在调谐电压的中间范围测得增益因子为1.21MHz/V,在偏离95.1MHz载波10kHz处的相位噪声为-88.6dBc/Hz,同时从3V电源汲取1.48mW的功耗,品质因数(FOM)为-166.5dBc/Hz。该压控振荡器成功地与一个带有700平方微米铱记录位点的穿透式硅微电极相连接,用于在距离约0.25m的体外无线记录来自盐溶液的50Hz模拟正常窦性心律信号。鉴于完全集成的前端生物放大器的典型增益约为40dB,采用该压控振荡器的无线记录微系统将能够检测低至亚毫伏范围的输入生物电位。