恶嗪170诱导DNA:RNA:DNA三链体形成。

Oxazine 170 induces DNA:RNA:DNA triplex formation.

作者信息

Song Guangtao, Xing Feifei, Qu Xiaogang, Chaires Jonathan B, Ren Jinsong

机构信息

Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China.

出版信息

J Med Chem. 2005 May 19;48(10):3471-3. doi: 10.1021/jm050131g.

DOI:10.1021/jm050131g

PMID:15887954

Abstract

The oxazine dye (Oxazine 170) was found to induce formation of a hybrid triplex structure, poly rA:(poly dT)(2), under solution conditions in which the triplex would not otherwise form. Formation of the hybrid triplex is driven by the structural selective binding of oxazine 170 to poly rA:(poly dT)(2). Oxazine 170 serves as a lead compound for the design of new compounds that can modulate triplex formation.

摘要

发现恶嗪染料（恶嗪170）在溶液条件下可诱导形成杂合三链体结构poly rA:(poly dT)(2)，而在其他情况下该三链体不会形成。杂合三链体的形成是由恶嗪170与poly rA:(poly dT)(2)的结构选择性结合驱动的。恶嗪170可作为设计能够调节三链体形成的新化合物的先导化合物。